Dire wolf lives again as world’s first de-extincted animal

Dire wolf lives again as world’s first de-extincted animal

By Rashika Kumar
08/04/2025

A species of wolf that died out some 12,500 years ago lives again as the world’s first successfully de-extincted animal, according to Dallas-based biotech company Colossal Biosciences.

Colossal scientists have created three dire wolf pups by using ancient DNA, cloning and gene-editing technology to alter the genes of a gray wolf, the prehistoric dire wolf’s closest living relative, the company announced Monday.

The result is essentially a hybrid species similar in appearance to its extinct forerunner.

The dire wolf, Aenocyon dirus, which was the inspiration for the fearsome canine featured in the HBO TV series “Game of Thrones,” was a top predator that once roamed North America.

The company says Dire wolves were larger in size than gray wolves and had a slightly wider head, light thick fur and stronger jaw.

Colossal has been working toward resurrecting the mammoth, dodo and Tasmanian tiger since 2021, but the company had not previously publicized its work on dire wolves.

Colossal’s cofounder and CEO Ben Lamm says this massive milestone is the first of many coming examples demonstrating that their end-to-end de-extinction technology stack works.

He says their team took DNA from a 13,000 year old tooth and a 72,000 year old skull and made healthy dire wolf puppies.

[Source: CNN]

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