Issak Fines-Leleiwasa and Isaiah Armstrong-Ravula will partner in the halves, while Manasa Mataele and Isikeli Basiyalo are on the wings.
Coach Glen Jackson has retained his centres Virimi Vakatawa and Tuidraki Samusamuvodre with Isikeli Rabitu starting at fullback.
Coming in off the bench are Kavaia Tagivetaua, Penaia Cakobau, Mesake Doge, Mesake Vocevoce, Joseva Tamani, Simione Kuruvoli, Kemu Valetini and Inia Tabuavou.
The Fijian Drua will play the Brumbies at 9.35pm Saturday.
In other matches, the Blues will meet the Highlanders at 7.05pm Friday, Moana Pasifika will meet the NSW Waratahs at 9.35pm, the Chiefs host the Hurricanes at 7.05pm Saturday, while the Force meet the Crusaders at 11.55pm.